Marc Cherry, the creator of Desperate Housewives, is also on board for the project.
The show resolves around Ruby Adair (played by McEntire), a sheriff in Oxblood, Ky., who finds her conservative outlook challenged when she enlists a young Middle Eastern FBI agent to help her solve an awful crime.
Reba will also serve as executive producer on the project, alongside Cherry.
"I am thrilled to be coming back home to ABC," Cherry said. "What makes it all the sweeter is Reba McEntire is coming with me. And we can't wait to share with our fans this wonderful Southern Gothic soap opera we've been cooking up for them."